I know your sitting down
and your going out and coming in,
and your raging against me.
God is not surprised, diminished, depressed or incapacitated by anyone's rejection of Him. God can handle it quite well. He has a sovereign plan in place to deal with everyone justly, including those who fight against Him with active rejection.
When Sennacherib came up against Jerusalem with the brutal power of the Assyrian army as his threat, he came mocking God. He ridiculed king Hezekiah but worst of all, he dared Israel's God to save them, as no pagan god had ever turned back the Assyrian superpower. The pride and swagger in Sennacherib's boasts seemed all too true to the citizens of Jerusalem. A brutal army outside the city gates prepared to bring Jerusalem to ruin. But the king of Assyria had never encountered the true God of heaven and earth. In response to a passionate prayer from Judah's king, God would humiliate the boastful Assyrian dictator.
God was intimately familiar with the situation. It did not catch Him off guard. Sennacherib's every move was God's intimate knowledge. He was well aware not only of the mocking voice of the Assyrian king, but also of his greatest weakness. In one night the entire army died in its sleep. And the Assyrian king, spared with only his life, quietly returned home impotent, only to die by assassination by the hands of his own sons later that year. God knew the raging of this king. He knew how to stop it. And He justly saw an end that would assert the glory of the God of Israel.
So over every person, institution, or movement that rages against God, the Lord is absolutely sovereign. Even the rejection of God by those who falsely trust human autonomy is orchestrated by God's hand for the ends of His glory and praise. When I see it in my day, I will be reminded of the humiliation of an ancient Assyrian loudmouth.